Tecovirimat: An Effective Antiviral Treatment for Monkeypox Viral Infection

woman inject boy on arm

Tecovirimat, also known by its brand name Tpoxx, represents a significant milestone in antiviral drug development, specifically targeting orthopoxvirus infections such as monkeypox. Tecovirimat was formulated to inhibit the activity of a protein essential for the virus’s ability to spread from an infected cell to others, effectively halting its proliferation within the host. This innovative … Read more

Ruxolitinib Shows Dramatic Improvement for Vitiligo

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Can a new treatment change the lives of those living with vitiligo? The recent TRuE-V1 Study suggests it can. Vitiligo, a chronic skin condition that causes white patches due to pigment loss, has long had limited treatment options. A new clinical trial, the Topical Ruxolitinib Evaluation in VItiligo Study 1 (TRuE-V1), has revealed a game-changing … Read more

Mechanism of Action of Donanemab-azbt for Alzhenimer’s

Mechanism of Action of Donanemab kisunla old ladies taking a selfie

Donanemab got FDA approval on 2nd July 2024. The mechanism of action of Donanemab-azbt (Kisunla) is detailed here to understand how this new molecule can be a life-changer for people with Alzheimer’s disease. Kisunla (Donanemab) is a special type of medicine known as a monoclonal antibody. Monoclonal antibodies are lab-made molecules designed to fight diseases … Read more

FDA Gives a Green Signal to a New Drug for Uncomplicated UTI

fda approved new drug for UTI

On 24th April 2024, the FDA approves pivmecillinam under the brand name Pivya for treating uncomplicated UTIs in adult women. Uncomplicated urinary tract infections are caused by microorganisms like Staphylococcus saprophyticus, Proteus mirabilis, and Escherichia coli. The UTI infections caused by the above-mentioned bacteria are more common than others and affect almost 50% of women … Read more

What is WINREVAIR (Sotatercept-csrk)?

what is WINREVAIR (Sotatercept-csrk) fda approved for PAH

WINREVAIR (Sotatercept-csrk) is a recombinant activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein. It blocks certain signals in the body. Specifically, it binds to and inhibits activin A and other TGF- β superfamily ligands. It corrects the imbalance between pro-proliferative (ActRIIA/Smad2/3-mediated) and anti-proliferative (BMPRII/Smad1/5/8 mediated) signaling mechanisms. By improving the bad inflammatory signals, it inhibits vascular … Read more

Daratumumab Mechanism of Action: Darzalex MOA

Daratumumab Mechanism of Action darzalex moa

Daratumumab Mechanism of Action: Daratumumab is a human monoclonal antibody. It is indicated for the treatment of Multiple Myeloma in the following situations: In Combination With … Daratumumab Indications Lenalidomide + dexamethasone Newly diagnosed Multiple Myeloma patients ineligible for autologous stem cell transplant OR Patients with relapsed or refractory multiple myeloma who have received at … Read more

Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum

Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum

The FDA approved Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum on 5th January 2024. Berdazimer Gel 10.3% (Zelsuvmi) is the second topical medicine approved so far for the treatment of Molluscum Contagiosum (MC). The first one, cantharidin, was approved in 2023. Curettage is more effective than Cantharidin. However, it has not been compared with Berdazimer … Read more

Why is Linzess Dangerous?

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Why is Linzess dangerous? All medicines can be dangerous. Linzess is a prescription medicine and it has its Pros and Cons. It is indicated for the treatment of chronic constipation and individuals with constipation-dominant IBS. Because it relieves constipation, one of the side effects can be diarrhea. Diarrhea can occur with any of the medications … Read more

Does Truqap (Capivasertib) Cause Hyperglycemia?

mTOR inhibitor Everolimus Afinitor trucap hyperglycemia

Yes! In clinical trials, hyperglycemia was reported in about 58% of the patients. TRUQAP (Capivasertib) is the most recently approved medicine for the treatment of breast cancer. It is recommended for women with the following [Ref]: Hormone receptor (HR)-positive, Human epidermal growth factor receptor 2 (HER2)-negative, Locally advanced or metastatic breast cancer with One or … Read more

Linzess MOA: Mechanism of Action of Linaclotide

linzess moa abdominal pain why is linzess dangerous

Linzess MOA (Mechanism of action) is different from most other medications used to treat constipation and IBS (Irritable Bowel Syndrome) such as Miralax. Linzess (Linaclotide) is the first-in-class medicine that acts on the intestinal epithelial cells and stimulates the transmembrane Guanylate Cyclase 2C receptors (GC-2C). Activation of guanylate cyclase 2 C receptors results in the … Read more