Tecovirimat: An Effective Antiviral Treatment for Monkeypox Viral Infection

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Tecovirimat, also known by its brand name Tpoxx, represents a significant milestone in antiviral drug development, specifically targeting orthopoxvirus infections such as monkeypox. Tecovirimat was formulated to inhibit the activity of a protein essential for the virus’s ability to spread from an infected cell to others, effectively halting its proliferation within the host. This innovative … Read more

What is WINREVAIR (Sotatercept-csrk)?

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WINREVAIR (Sotatercept-csrk) is a recombinant activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein. It blocks certain signals in the body. Specifically, it binds to and inhibits activin A and other TGF- β superfamily ligands. It corrects the imbalance between pro-proliferative (ActRIIA/Smad2/3-mediated) and anti-proliferative (BMPRII/Smad1/5/8 mediated) signaling mechanisms. By improving the bad inflammatory signals, it inhibits vascular … Read more

Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum

Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum

The FDA approved Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum on 5th January 2024. Berdazimer Gel 10.3% (Zelsuvmi) is the second topical medicine approved so far for the treatment of Molluscum Contagiosum (MC). The first one, cantharidin, was approved in 2023. Curettage is more effective than Cantharidin. However, it has not been compared with Berdazimer … Read more

Zavegepant Nasal Spray (Zavzpret) for Migraine

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Zavegepant Nasal Spray (Zavzpret) is a small-molecule, competitive antagonist of the calcitonin gene-related peptide (CGRP) receptor, which is a target for the treatment of migraine. CGRP is a neuropeptide that is found in high levels in the trigeminal nerve, which is believed to play a role in migraine pathogenesis. CGRP exerts its effects on the vasculature, … Read more

mTOR Inhibitor Everolimus (Afinitor): MOA, Side effects, Dose

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Novartis’ Afinitor (everolimus) was approved by the FDA on February 26, 2016, for the treatment of adult patients with unresectable, locally advanced or metastatic progressive, well-differentiated non-functional neuroendocrine tumors (NETs) originating from the gastrointestinal or lung areas. Afinitor, also known as everolimus, is a type of medication categorized as an mTOR inhibitor. It is available … Read more

Weight Regain after Stopping Ozempic: What to do?

ozempic weight regain

Ozempic (Semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate blood sugar levels and reduce appetite, leading to weight loss. However, once you stop taking the medication, your appetite and blood sugar levels may return to pre-treatment levels, which could cause weight gain. It’s important to remember that weight loss and weight management … Read more