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Tysabri (Natalizumab) MOA and Indications

Tysabri contains “Natalizumab” considered an evolution in the management of many autoimmune diseases. It is manufactured by Biogen Company and got FDA approval in 2004. In 2005 the drug was voluntarily withdrawn from the U.S. market when cases of progressive multifocal leukoencephalopathy were reported. However, it was again approved by FDA in 2006 due to…

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Tofacitinib Mechanism of Action: Xeljanz MOA

Tofacitinib is an oral Janus Kinase Inhibitor. Because of its unique and novel mechanism of action, it is one of the potent JAK Inhibitors. It was approved by the FDA in 2012. It is available in two formulations: Immediate Release as Xeljanz, and The Extended Release Oral Tablets as Xeljanz XR Tofacitinib is a Janus…

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Rinvoq (Upadacitinib) Mechanism of Action (MOA)

Upadacitinib is among the novel class of medicines with a unique mechanism of action (MOA). It is available by the brand name, Rinvoq that has been approved in 2019 by the FDA. Among the biological medications, it is one of the few medicines that are available as oral tablet formulations with once-daily dosing. Rinvoq Indications:…

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Trulicity Side effects: Depression, Mood Swings, Anxiety

Trulicity side effects are primarily GI-related. Most patients develop nausea, vomiting, bloating, and abdominal fullness. Little is known about the neurological side effects of Trulicity. However, post-marketing reports of patients who have developed neurological side effects are being reported. Side effects of Semaglutide (Rybelsus, Ozempic, and Wegovy) What is Trulicity? Trulicity is the brand name…

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Tirzepatide Side effects and How to Manage Them

Tirzepatide Side effects may range from mild gastrointestinal side effects to serious life-threatening pancreatitis and kidney failure. Like the GLP-1 agonists, Semaglutide, Liraglutide, Dulaglutide, etc, it primarily acts in the gastrointestinal tract. Hence, most of the GI side effects are related to the gastrointestinal tract. What is Tirzepatide? It is the first of its class…

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