chronic constipation

Linzess MOA: Mechanism of Action of Linaclotide

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Linzess MOA (Mechanism of action) is different from most other medications used to treat constipation and IBS (Irritable Bowel Syndrome) such as Miralax. Linzess (Linaclotide) is the first-in-class medicine that acts on the intestinal epithelial cells and stimulates the transmembrane Guanylate Cyclase 2C receptors (GC-2C). Activation of guanylate cyclase 2 C receptors results in the … Read more

Lubiprostone (Amitiza) – Can It Really Help With Constipation?

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Lubiprostone is marketed by the brand name Amitiza. It is a locally acting drug that primarily activates the intestinal chloride channels and increases the fluid in the digested food, relieving constipation. Unlike Trulance and Linzess (Plecanatide and Linaclotide), Amitiza (Lubiprostone) acts on the chloride channels and activates them. Trulance and Linzess are drugs used for … Read more