Donanemab got FDA approval on 2nd July 2024. The mechanism of action of Donanemab-azbt (Kisunla) is detailed here to understand how this new molecule can be a life-changer for people with Alzheimer’s disease. Kisunla (Donanemab) is a special type of medicine known as a monoclonal antibody. Monoclonal antibodies are lab-made molecules designed to fight diseases … Read more
On 24th April 2024, the FDA approves pivmecillinam under the brand name Pivya for treating uncomplicated UTIs in adult women. Uncomplicated urinary tract infections are caused by microorganisms like Staphylococcus saprophyticus, Proteus mirabilis, and Escherichia coli. The UTI infections caused by the above-mentioned bacteria are more common than others and affect almost 50% of women … Read more
WINREVAIR (Sotatercept-csrk) is a recombinant activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein. It blocks certain signals in the body. Specifically, it binds to and inhibits activin A and other TGF- β superfamily ligands. It corrects the imbalance between pro-proliferative (ActRIIA/Smad2/3-mediated) and anti-proliferative (BMPRII/Smad1/5/8 mediated) signaling mechanisms. By improving the bad inflammatory signals, it inhibits vascular … Read more
Daratumumab Mechanism of Action: Daratumumab is a human monoclonal antibody. It is indicated for the treatment of Multiple Myeloma in the following situations: In Combination With … Daratumumab Indications Lenalidomide + dexamethasone Newly diagnosed Multiple Myeloma patients ineligible for autologous stem cell transplant OR Patients with relapsed or refractory multiple myeloma who have received at … Read more
The FDA approved Berdazimer Gel 10.3% (Zelsuvmi) for Molluscum Contagiosum on 5th January 2024. Berdazimer Gel 10.3% (Zelsuvmi) is the second topical medicine approved so far for the treatment of Molluscum Contagiosum (MC). The first one, cantharidin, was approved in 2023. Curettage is more effective than Cantharidin. However, it has not been compared with Berdazimer … Read more
Why is Linzess dangerous? All medicines can be dangerous. Linzess is a prescription medicine and it has its Pros and Cons. It is indicated for the treatment of chronic constipation and individuals with constipation-dominant IBS. Because it relieves constipation, one of the side effects can be diarrhea. Diarrhea can occur with any of the medications … Read more
Yes! In clinical trials, hyperglycemia was reported in about 58% of the patients. TRUQAP (Capivasertib) is the most recently approved medicine for the treatment of breast cancer. It is recommended for women with the following [Ref]: Hormone receptor (HR)-positive, Human epidermal growth factor receptor 2 (HER2)-negative, Locally advanced or metastatic breast cancer with One or … Read more
Linzess MOA (Mechanism of action) is different from most other medications used to treat constipation and IBS (Irritable Bowel Syndrome) such as Miralax. Linzess (Linaclotide) is the first-in-class medicine that acts on the intestinal epithelial cells and stimulates the transmembrane Guanylate Cyclase 2C receptors (GC-2C). Activation of guanylate cyclase 2 C receptors results in the … Read more
Veltassa belongs to the class of drugs called “potassium-binding resins”. Its actual name or medical name is Patiromer Sorbitex Calcium. It binds to the dietary potassium that we ingest and prevents its absorption. In exchange, it releases its calcium, hence it is a calcium-exchange potassium-binding resin. Although very specific and a much safer option than … Read more
Zavegepant Nasal Spray (Zavzpret) is a small-molecule, competitive antagonist of the calcitonin gene-related peptide (CGRP) receptor, which is a target for the treatment of migraine. CGRP is a neuropeptide that is found in high levels in the trigeminal nerve, which is believed to play a role in migraine pathogenesis. CGRP exerts its effects on the vasculature, … Read more