TNF Inhibitors – An Overview of Their Use in Immune-mediated Diseases

tnf inhibitors classification

TNF inhibitors are being increasingly used in the treatment of various immune-mediated diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, and psoriasis. There are five tumor necrosis factor inhibitors available to treat rheumatoid arthritis and other immune-mediated diseases worldwide. Biosimilar versions of TNF inhibitors are now available in certain countries. Additional biosimilar agents … Read more

Nintedanib (Ofev) for Pulmonary Fibrosis: Dose, MOA, Side effects

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Nintedanib (Ofev) is a small tyrosine kinase inhibitor that is used to treat patients with idiopathic pulmonary fibrosis, interstitial lung disease in patients with systemic sclerosis, and non-small cell lung cancer. Overview of Nintedanib and its indications: Nintedanib (Ofev) is a small tyrosine kinase inhibitor that primarily targets platelet-derived growth factor receptors (PDGFR), Fibroblast growth … Read more

Simponi vs Humira (Golimumab Vs Adalimumab) – Comparison

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Simponi Vs Humira (Golimumab vs Adalimumab) is a comparison of the two novel TNF inhibitors. Both of these drugs are TNF (Tumor Necrosis Factor) Inhibitors. Their function is to reduce inflammation in different disease conditions. These two drugs will be compared based on the mechanism of action, dosage formulations, pharmacokinetics, and efficacy in different conditions. Indications … Read more

Lubiprostone (Amitiza) – Can It Really Help With Constipation?

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Lubiprostone is marketed by the brand name Amitiza. It is a locally acting drug that primarily activates the intestinal chloride channels and increases the fluid in the digested food, relieving constipation. Unlike Trulance and Linzess (Plecanatide and Linaclotide), Amitiza (Lubiprostone) acts on the chloride channels and activates them. Trulance and Linzess are drugs used for … Read more

Trulance VS Linzess (Plecanatide Vs Linaclotide): A Comprehensive Comparison

Trulance vs linzes plecanatide vs linaclotide in CIC and IBS-C

Trulance VS Linzess (Plecanatide Vs Linaclotide) are two novel medicines that are being increasingly used to treat patients with chronic idiopathic constipation and Irritable bowel syndrome with predominant symptoms of constipation. Trulance Vs Linzess (Plecanatide Vs Linaclotide) What is Trulance? Trulance is the brand name of Plecanatide. It relieves constipation by acting as a guanylate … Read more

Dupilumab MOA (Mechanism of action of Dupixent)

dupilumab moa mechanism of action of dupilumab in astham and atopic dermatitis

Dupilumab MOA (mechanism of action of Dupilumab) is discussed here. It inhibits IL-4 and IL-13 signaling pathways and IgE-mediated inflammation. Dupilumab (generic name) is available by the brand name of Dupixent (Regeneron Pharmaceuticals, Inc). It is used to treat patients with moderate to severe atopic dermatitis with or without concomitant use of topical corticosteroids. It … Read more

Simponi vs Enbrel (Golimumab Vs Etanercept) – Comparison

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Simponi vs Enbrel is a comparison of the two TNF-inhibitors, Golimumab and Etanercept. Both Simponi (Golimumab) and Enbrel (Etanercept) aim to reduce the process of inflammation by decreasing the production of Interleukin-6 and Interleukin-8. Owing to their strong immune-modulatory effects, these drugs are commonly used to treat autoimmune rheumatic conditions like ankylosing spondylitis, psoriatic arthritis, … Read more

Rituximab VS Obinutuzumab (Rituxan Vs Gazyva) Comparison

Rituximab VS Obinutuzumab rituxan vs gazyva in ra lymphoma vasculitis graft rejection

Rituximab VS Obinutuzumab is a comparison of the two monoclonal antibodies that target the CD-20 B-lymphocytes. Obinutuzumab is a newer generation anti-CD 20 monoclonal antibody with greater efficacy and immune suppression. Obinutuzumab is believed to be twice as effective as Rituximab Drug Description: Rituximab Obinutuzumab Targets: Monoclonal type I CD20 antibody Monoclonal type II CD20 … Read more

Cymbalta Vs Lyrica Vs Neurontin: Duloxetine Vs Pregabalin Vs Gabapentin

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Cymbalta (Duloxetine) Vs Lyrica (Pregabalin) Vs Neurontin (Gabapentin) is a comparison of the three commonly used drugs in the treatment of patients with diabetic neuropathy, anxiety, depression, and low back pain. Cymbalta Vs Lyrica Vs Neurontin Duloxetine (Cymbalta) is prescribed for the treatment of patients with diabetic neuropathy, depression, and chronic pain. Lyrica (Pregabalin) is … Read more

Eliquis Vs Plavix (Comparison of Apixaban and Clopidogrel)

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Eliquis Vs Plavix is a comparison of the two commonly used blood thinners, Apixaban and Clopidogrel. Both drugs have different mechanisms of action and different indications. Generally speaking, Apixaban is an anticoagulant and Clopidogrel is a platelet inhibitor. Drug Description of Eliquis and Plavix: Eliquis (Apixaban) Eliquis generic name is Apixaban. It is a widely … Read more