Sacubitril Valsartan (ARNI) – Entresto Mechanism of Action in HFrEF

entresto mechanism of action arni sacubitril valsartan angiotensin receptor neprilysin inhibitor

Sacubitril Valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI in short). It is available by the brand names Entresto and Uperio. Entersto mechanism of action is unique and is especially recommended in patients with Heart Failure and reduced Ejection Fraction. Entresto is a combination of a neprilysin antagonist (Sacubitril) and an ARB (Valsartan).┬áThis combination drug was … Read more

Dupilumab MOA (Mechanism of action of Dupixent)

dupilumab moa mechanism of action of dupilumab in astham and atopic dermatitis

Dupilumab MOA (mechanism of action of Dupilumab) is discussed here. It inhibits IL-4 and IL-13 signaling pathways and IgE-mediated inflammation. Dupilumab (generic name) is available by the brand name of Dupixent (Regeneron Pharmaceuticals, Inc). It is used to treat patients with moderate to severe atopic dermatitis with or without concomitant use of topical corticosteroids. It … Read more

Leuprolide MOA (Mechanism of action of Leuprolide Acetate)

leuprolide agonist activity leuprolide moa

Leuprolide MOA (Mechanism of action of Leuprolide) is discussed here in detail.┬áLeuprolide Acetate is used as monotherapy or in combination with norethindrone for the treatment of various conditions listed below: Leuprolide acetate monthly depot injection is used for the palliative treatment of advanced prostatic carcinoma. For the treatment and prevention of recurrence of Endometriosis. It … Read more

Patiromer MOA, Vs Lokelma (Sodium Zirconium Cyclosilicate) Vs SPS

patiromer moa (Veltassa moa) Sodium Zirconium Cyclosilicate (Lokelma) moa, sps kayexalate moa

Patiromer MOA is similar to Sodium Zirconium Cyclosilicate (Lokelma) and Sodium Polystyrene sulfonate (SPS, Kayexalate). These remove the excess potassium from the body. Patiromer (Veltassa), Sodium Zirconium Cyclosilicate (Lokelma), and Sodium Polystyrene Sulfonate (Kayexalate) are the three potassium binding resins that have a slightly different mechanism of action (MOA), however, all of them bind to … Read more

Trodelvy Mechanism of Action (Sacituzumab MOA)

Trodelvy Mechanism of Action (Sacituzumab MOA)

Sacituzumab marketed by the brand name of Trodelvy (Gilead Sciences) is FDA approved for the treatment of patients with advanced breast cancer and urothelial cancer. Trodelvy mechanism of action in the treatment of these cancers is a little complicated to understand. It is therefore important to define a few terminologies before discussing the MOA of … Read more