Skyrizi vs Tremfya (Risankizumab Vs Guselkumab) – Comparison

Skyrizi vs Tremfya (Risankizumab Vs Guselkumab) is a comparison of the two monoclonal antibodies which selectively target and block Interleukin-23. IL-23 is an inflammatory cytokine that activates CD4 + T-helper (Th17) cell pathway to activate the inflammation cascade that is responsible for psoriatic plaque formation.  Both of these drugs are indicated in the treatment of … Read more

Plerixafor (Mozobil) – Uses, Dose, MOA, Brands, Side effects

Plerixafor is a class of drugs called hematopoietic stem cell mobilizer. When combined with filgrastim, a colony stimulating factor, it mobilizes CD-34 positive cells that have repopulating capabilities. Indications of Plerixafor: It is a used to mobilize hematopoietic cells (HSCs) which are then used for collection and subsequent autologous transfer (in combination with filgrastim), in … Read more

Serotonin Modulators – Nefazodone, Trazodone, Vilazodone, Vortioxetine

Serotonin Modulators are a class of medicines that are different from SSRIs (selective serotonin reuptake inhibitors), SNRIs (selective norepinephrine reuptake inhibitors), MAO inhibitors (monoamine oxidase inhibitors), TCAs (Tricyclic antidepressants), and atypical antidepressants. The four drugs included in the serotonin modulators are: Nefazodone (Serzone) Trazodone (Oleptro) Vilazodone (Viibryd) Vortioxetine (Brintellix) The serotonin modulators are distinct from … Read more

Simponi Vs Cimzia (Golimumab Vs Certolizumab) – Comparisons

simponi vs cimzia golimumab vs certolizumab uses differences

Simponi vs Cimzia is a comparison of the two novel TNF-inhibitors. Both the drugs can be administered as slow intravenous infusions or subcutaneous injections. This article explains the comparative pharmacokinetics, mechanism of action, and efficacies of two TNF inhibitors Simponi (golimumab) and Cimzia (certolizumab) in various conditions. Both of these drugs are indicated in chronic … Read more

Vortioxetine (Brintellix, Trintellix) Side effects Including Sexual

vortioxetine side effects brintellix trintellix

Vortioxetine Side effects that are common include nausea, dyspepsia, diarrhea, constipation, and sexual side effects. Most of the side effects are related to the central nervous system. A detail of the side effects of Vortioxetine is reviewed here. A piece of advice regarding how to overcome these side effects is also discussed. What is Vortioxetine? … Read more

Sacubitril Valsartan (ARNI) – Entresto Mechanism of Action in HFrEF

entresto mechanism of action arni sacubitril valsartan angiotensin receptor neprilysin inhibitor

Sacubitril Valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI in short). It is available by the brand names Entresto and Uperio. Entersto mechanism of action is unique and is especially recommended in patients with Heart Failure and reduced Ejection Fraction. Entresto is a combination of a neprilysin antagonist (Sacubitril) and an ARB (Valsartan). This combination drug was … Read more

Simponi vs Remicade (Golimumab Vs Infliximab)

simponi vs remicade golimumab vs infliximab

Simponi vs Remicade is a comparison between two drugs Simponi (Golimumab) and Remicade (Infliximab). Both of them are TNF (Tumor Necrosis Factor) Inhibitors. These drugs aid in the treatment of chronic inflammation in various conditions. This comparison is based on the mechanism of action, pharmacokinetics, and efficacy in different conditions. Indications and Uses: Simponi vs … Read more

Rituximab Vs Infliximab (Rituxan Vs Remicade) – Comparison

rituximab vs infliximab rituxan vs remicade

Rituximab Vs Infliximab is a comparison of the two drugs. Rituximab is a monoclonal antibody that targets CD-20 Positive B Lymphocytes While Infliximab is a TNF Inhibitor. Drug Description: Rituximab Vs Infliximab: Rituximab Infliximab Class Monoclonal type I CD20 antibody Tumor necrosis factor (TNF-alpha or TNF-α) blocker Chimeric Monoclonal IgG1 antibody Trade Names MabThera, Rixathon, … Read more

Biologics for Psoriasis (TNF, IL-23, IL-39, IL-17, and CD-6 Inhibitors)

biologics for psoriasis

Biologics for Psoriasis are used in patients who have moderate to severe disease or are not responsive to conventional therapies. Biologics for psoriasis are both effective and tolerable. They have good short-term and long-term efficacy. The most common side effect associated with the use of biologics for psoriasis is the increased incidence of infections. TNF-alpha … Read more